TTLL5 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant TTLL5.
Immunogen
Recombinant protein corresponding to amino acids of human TTLL5.
Sequence
NKHHSGIAKTQKEGEDASLYSKRYNQSMVTAELQRLAEKQAARQYSPSSHINLLTQQVTNLNLATGIINRSSASAPPTLRPIISPSGP
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:200-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human heart muscle with TTLL5 polyclonal antibody (Cat # PAB22614) shows distinct positivity in endothelial cells. -
Gene Info — TTLL5
Entrez GeneID
23093Protein Accession#
Q6EMB2Gene Name
TTLL5
Gene Alias
KIAA0998, MGC117189, STAMP
Gene Description
tubulin tyrosine ligase-like family, member 5
Gene Ontology
HyperlinkGene Summary
TTLL5 is a glucocorticoid receptor (GCCR; MIM 138040) coregulator that interacts with coactivators TIF2 (NCOA2; MIM 601993) and SRC1 (NCOA1; MIM 602691) (He and Simons, 2007 [PubMed 17116691]).[supplied by OMIM
Other Designations
SRC1 and TIF2 associated binding protein
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Interactome
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Publication Reference
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Biallelic Variants in TTLL5, Encoding a Tubulin Glutamylase, Cause Retinal Dystrophy.
Sergouniotis PI, Chakarova C, Murphy C, Becker M, Lenassi E, Arno G, Lek M, MacArthur DG, UCL-Exomes Consortium, Bhattacharya SS, Moore AT, Holder GE, Robson AG, Wolfrum U, Webster AR, Plagnol V.
American Journal of Human Genetics 2014 May; 94(5):760.
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Biallelic Variants in TTLL5, Encoding a Tubulin Glutamylase, Cause Retinal Dystrophy.
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