Western blot analysis of PMAT (SLC29A4) (arrow) using rabbit SLC29A4 polyclonal antibody (Cat # PAB2256). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PMAT (SLC29A4) gene (Lane 2) (Origene Technologies).
This gene is a member of the SLC29 family and encodes a plasma membrane protein with 11 transmembrane helices. This protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq