MKL1 polyclonal antibody
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More Files
- More Functions
Western Blot
Western blot analysis of Lane 1: RT-4, Lane 2: U-251 MG, Lane 3: Human Plasma, Lane 4: Liver, Lane 5: Tonsil with MKL1 polyclonal antibody (Cat # PAB22486) at 1:250-1:500 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human placenta with MKL1 polyclonal antibody (Cat # PAB22486) shows strong nuclear positivity in decidual cells at 1:20-1:50 dilution.
Immunofluorescence
Immunofluorescent staining of human cell line A-431 with MKL1 polyclonal antibody (Cat # PAB22486) at 1-4 ug/mL dilution shows positivity in nucleus but not nucleoli.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant MKL1.
Immunogen
Recombinant protein corresponding to amino acids of human MKL1.
Sequence
EQEKRAQQPAPAPAPLGTPVKQENSFSSCQLSQQPLGPAHPFNPSLAAPATNHIDPCAVAPGPPSVVVKQEALQPEPEPVPAPQLLLGPQGPSLIKGVAPPTLITDSTGTHLVLTVTNKNADSPG
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:20-1:50)
Western Blot (1:250-1:500)
Immunofluorescence (1-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of Lane 1: RT-4, Lane 2: U-251 MG, Lane 3: Human Plasma, Lane 4: Liver, Lane 5: Tonsil with MKL1 polyclonal antibody (Cat # PAB22486) at 1:250-1:500 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human placenta with MKL1 polyclonal antibody (Cat # PAB22486) shows strong nuclear positivity in decidual cells at 1:20-1:50 dilution.Immunofluorescence
Immunofluorescent staining of human cell line A-431 with MKL1 polyclonal antibody (Cat # PAB22486) at 1-4 ug/mL dilution shows positivity in nucleus but not nucleoli. -
Gene Info — MKL1
Entrez GeneID
57591Protein Accession#
Q969V6Gene Name
MKL1
Gene Alias
BSAC, MAL, MRTF-A
Gene Description
megakaryoblastic leukemia (translocation) 1
Omim ID
606078Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. [provided by RefSeq
Other Designations
OTTHUMP00000028831|RBM15/MKL1 fusion|RNA-binding motif protein 15/megakaryoblastic leukemia-1 fusion protein|basic, SAP and coiled-coil domain|megakaryoblastic leukemia 1|megakaryoblastic leukemia 1 protein|megakaryocytic acute leukemia|myocardin-related
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Interactome
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Disease
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