HTATIP polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of HTATIP polyclonal antibody (Cat # PAB2247) in mouse liver tissue lysate (35 ug/lane). HTATIP (arrow) was detected using the purified polyclonal antibody.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of HTATIP.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human HTATIP.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of HTATIP polyclonal antibody (Cat # PAB2247) in mouse liver tissue lysate (35 ug/lane). HTATIP (arrow) was detected using the purified polyclonal antibody. -
Gene Info — KAT5
Entrez GeneID
10524Protein Accession#
NP_006379;Q92993Gene Name
KAT5
Gene Alias
ESA1, HTATIP, HTATIP1, PLIP, TIP, TIP60, cPLA2
Gene Description
K(lysine) acetyltransferase 5
Omim ID
601409Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq
Other Designations
HIV-1 Tat interactive protein, 60kDa|K-acetyltransferase 5|Tat interacting protein, 60kDa|cPLA2 interacting protein
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Interactome
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Publication Reference
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The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes.
Cai Y, Jin J, Florens L, Swanson SK, Kusch T, Li B, Workman JL, Washburn MP, Conaway RC, Conaway JW.
The Journal of Biological Chemistry 2005 Apr; 280(14):13665.
Application：WB-Tr, Human, HeLa cells.
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The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60.
Patel JH, Du Y, Ard PG, Phillips C, Carella B, Chen CJ, Rakowski C, Chatterjee C, Lieberman PM, Lane WS, Blobel GA, McMahon SB.
Molecular and Cellular Biochemistry 2004 Dec; 24(24):10826.
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Role of the histone acetyl transferase Tip60 in the p53 pathway.
Legube G, Linares LK, Tyteca S, Caron C, Scheffner M, Chevillard-Briet M, Trouche D.
The Journal of Biological Chemistry 2004 Oct; 279(43):44825.
Application：IF, Human, U-2 OS cells.
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The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes.
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