GCN5L2 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of GCN5L2 polyclonal antibody (Cat # PAB2244) in 293 cell line lysates (35 ug/lane). GCN5 (arrow) was detected using the purified polyclonal antibody.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GCN5L2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human GCN5L2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of GCN5L2 polyclonal antibody (Cat # PAB2244) in 293 cell line lysates (35 ug/lane). GCN5 (arrow) was detected using the purified polyclonal antibody. -
Gene Info — KAT2A
Entrez GeneID
2648Protein Accession#
NP_066564;Q8N1A2Gene Name
KAT2A
Gene Alias
GCN5, GCN5L2, MGC102791, PCAF-b, hGCN5
Gene Description
K(lysine) acetyltransferase 2A
Omim ID
602301Gene Ontology
HyperlinkGene Summary
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM
Other Designations
GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2|GCN5 general control of amino-acid synthesis 5-like 2|General control of amino acid synthesis, yeast, homolog-like 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription.
Sabo A, Lusic M, Cereseto A, Giacca M.
Molecular and Cellular Biology 2008 Feb; 28(7):2201.
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Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5.
Wiper-Bergeron N, Salem HA, Tomlinson JJ, Wu D, Hache RJ.
PNAS 2007 Feb; 104(8):2703.
Application：WB, Mouse, 3T3-L1 cells.
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An hGCN5/TRRAP histone acetyltransferase complex co-activates BRCA1 transactivation function through histone modification.
Oishi H, Kitagawa H, Wada O, Takezawa S, Tora L, Kouzu-Fujita M, Takada I, Yano T, Yanagisawa J, Kato S.
The Journal of Biological Chemistry 2005 Oct; 281(1):20.
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Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription.
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