Immunohistochemical staining of human pancreas with MLLT4 polyclonal antibody (Cat # PAB22418) shows moderate cytoplasmic and strong luminal membranous positivity in exocrine cells at 1:200-1:500 dilution.
Immunofluorescent staining of human cell line U-251MG with MLLT4 polyclonal antibody (Cat # PAB22418) at 1-4 ug/mL dilution shows positivity in plasma membrane and cell junctions.
AF6 is a Ras (see HRAS; MIM 190020) target that regulates cell-cell adhesions downstream of Ras activation. It is fused with MLL (MIM 159555) in leukemias caused by t(6;11) translocations (Taya et al., 1998 [PubMed 9722616]).[supplied by OMIM
OTTHUMP00000017632,myeloid/lymphoid or mixed-lineage leukemia, translocated to, 4