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Last updated: 2017/10/15
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MBD2 polyclonal antibody

  • Catalog # : PAB2234
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of MBD2.
  • Immunogen:
  • A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human MBD2.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse
  • Form:
  • Liquid
  • Purification:
  • Protein G purification
  • Recommend Usage:
  • Western Blot (1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot
  • Western Blot
  • The MBD2 polyclonal antibody (Cat # PAB2234) is used in Western blot to detect MBD2 in A-375 cell lysate (lane 1) and mouse brain tissue lysate (lane 2) lysate.
  • Application Image
  • Gene Information
  • Entrez GeneID:
  • 8932
  • Gene Name:
  • MBD2
  • Gene Alias:
  • DKFZp586O0821,DMTase,NY-CO-41
  • Gene Description:
  • methyl-CpG binding domain protein 2
  • Gene Summary:
  • DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. [provided by RefSeq
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