MBD2 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MBD2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human MBD2.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
The MBD2 polyclonal antibody (Cat # PAB2234) is used in Western blot to detect MBD2 in A-375 cell lysate (lane 1) and mouse brain tissue lysate (lane 2) lysate. -
Gene Info — MBD2
Entrez GeneID
8932Protein Accession#
AAC68871Gene Name
MBD2
Gene Alias
DKFZp586O0821, DMTase, NY-CO-41
Gene Description
methyl-CpG binding domain protein 2
Omim ID
603547Gene Ontology
HyperlinkGene Summary
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. [provided by RefSeq
Other Designations
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Interactome
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Disease
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Publication Reference
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Methyl-CpG-binding domain 2: a protective role in bladder carcinoma.
Zhu Y, Spitz MR, Zhang H, Grossman HB, Frazier ML, Wu X.
Cancer 2004 May; 100(9):1853.
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Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression.
Ghoshal K, Majumder S, Datta J, Motiwala T, Bai S, Sharma SM, Frankel W, Jacob ST.
The Journal of Biological Chemistry 2004 Feb; 279(8):6783.
Application:IF, WB-Tr, Human, HepG2 cells.
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Antithetic effects of MBD2a on gene regulation.
Fujita H, Fujii R, Aratani S, Amano T, Fukamizu A, Nakajima T.
Molecular and Cellular Biology 2003 Apr; 23(8):2645.
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Methyl-CpG-binding domain 2: a protective role in bladder carcinoma.
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