H3F3A/H3F3B polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of H3F3A, H3F3B.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human H3 histone.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of H3F3A/H3F3B polyclonal antibody (Cat # PAB2227) in CEM cell line lysates (35 ug/lane). Histone H3 (arrow) was detected using the purified polyclonal antibody. -
Gene Info — H3F3A
Entrez GeneID
3020Protein Accession#
P84243 (Gene ID : 3020);NP_002098 (Gene ID : 3020);NP_005315 (Gene ID : 3021);NP_005315 (Gene ID : 3021)Gene Name
H3F3A
Gene Alias
H3.3A, H3F3, MGC87782, MGC87783
Gene Description
H3 histone, family 3A
Omim ID
601128Gene Ontology
HyperlinkGene Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. [provided by RefSeq
Other Designations
OTTHUMP00000035618|OTTHUMP00000035619|OTTHUMP00000035621
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Gene Info — H3F3B
Entrez GeneID
3021Protein Accession#
P84243 (Gene ID : 3020);NP_002098 (Gene ID : 3020);NP_005315 (Gene ID : 3021);NP_005315 (Gene ID : 3021)Gene Name
H3F3B
Gene Alias
H3.3B, H3F3A
Gene Description
H3 histone, family 3B (H3.3B)
Omim ID
601058Gene Ontology
HyperlinkGene Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is poyadenylated, unlike most histone genes. The protein encoded is a member of the histone H3 family. [provided by RefSeq
Other Designations
H3 histone, family 3A|H3 histone, family 3B
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Interactome
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Pathway
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Disease
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Publication Reference
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The human and mouse replication-dependent histone genes.
Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ.
Genomics 2002 Nov; 80(5):487.
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The human histone gene cluster at the D6S105 locus.
Albig W, Doenecke D.
Human Genetics 1997 Dec; 101(3):284.
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Human histone gene organization: nonregular arrangement within a large cluster.
Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D.
Genomics 1997 Mar; 40(2):314.
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The human and mouse replication-dependent histone genes.
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