SLC12A3 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human kidney with SLC12A3 polyclonal antibody (Cat # PAB22213) shows strong cytoplasmic positivity in cells in tubules at 1:50-1:200 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant SLC12A3.
Immunogen
Recombinant protein corresponding to amino acids of human SLC12A3.
Sequence
LLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSS
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human kidney with SLC12A3 polyclonal antibody (Cat # PAB22213) shows strong cytoplasmic positivity in cells in tubules at 1:50-1:200 dilution. -
Gene Info — SLC12A3
Entrez GeneID
6559Protein Accession#
P55017Gene Name
SLC12A3
Gene Alias
FLJ96318, NCCT, TSC
Gene Description
solute carrier family 12 (sodium/chloride transporters), member 3
Gene Ontology
HyperlinkGene Summary
This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
Na-Cl symporter|NaCl electroneutral thiazide-sensitive cotransporter|sodium-chloride cotransporter, thiazide-sensitive|solute carrier family 12, member 3|thiazide-sensitive Na-Cl cotransporter
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Interactome
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Disease
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