CHD1L polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant CHD1L.
Immunogen
Recombinant protein corresponding to amino acids of human CHD1L.
Sequence
GSRDQEEGKNHMYLFEGKDYSKEPSKEDRKSFEQLVNLQKTLLEKASQEGRSLRNKGSVLIPGLVEGSTKRKRVLSPEELEDRQKKRQEAAAKRRRLIEEKKR
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:500-1:1000)
Western Blot (1:250-1:500)
Immunofluorescence (1-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of Lane 1: RT-4, Lane 2: U-251 MG, Lane 3: Human Plasma, Lane 4: Liver, Lane 5: Tonsil with CHD1L polyclonal antibody (Cat # PAB22203) at 1:250-1:500 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human testis with CHD1L polyclonal antibody (Cat # PAB22203) shows strong positivity in germ cells at 1:500-1:1000 dilution.Immunofluorescence
Immunofluorescent staining of human cell line U-2 OS with CHD1L polyclonal antibody (Cat # PAB22203) at 1-4 ug/mL dilution shows positivity in nucleus but not nucleoli. -
Gene Info — CHD1L
Entrez GeneID
9557Protein Accession#
Q86WJ1Gene Name
CHD1L
Gene Alias
ALC1, CHDL, FLJ22530
Gene Description
chromodomain helicase DNA binding protein 1-like
Gene Ontology
HyperlinkGene Summary
In response to DNA strand breaks, chromatin adopts a relaxed structure due to the addition of poly(ADP-ribose) (PAR) to chromatin proteins by PARP enzymes (see PARP1; MIM 173870), and this relaxation facilitates the repair of DNA damage. CHD1L interacts with PAR and has a role in chromatin relaxation following DNA damage (Ahel et al., 2009 [PubMed 19661379]).[supplied by OMIM
Other Designations
OTTHUMP00000016308
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Interactome
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Disease
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