JMJD6 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of JMJD6.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human JMJD6.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of JMJD6 polyclonal antibody (Cat # PAB2219) in mouse heart, Hela, and HL-60 cell line lysates. PTDSR (N-term) (arrow) was detected using the purified polyclonal antibody. -
Gene Info — JMJD6
Entrez GeneID
23210Protein Accession#
NP_055982;Q6AYK2Gene Name
JMJD6
Gene Alias
KIAA0585, PSR, PTDSR, PTDSR1
Gene Description
jumonji domain containing 6
Omim ID
604914Gene Ontology
HyperlinkGene Summary
This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
phosphatidylserine receptor
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Interactome
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Publication Reference
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Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis.
Vandivier RW, Fadok VA, Hoffmann PR, Bratton DL, Penvari C, Brown KK, Brain JD, Accurso FJ, Henson PM.
The Journal of Clinical Investigation 2002 Mar; 109(5):661.
Application:Flow Cyt, Human, Human monocyte-derived macrophages.
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A receptor for phosphatidylserine-specific clearance of apoptotic cells.
Fadok VA, Bratton DL, Rose DM, Pearson A, Ezekewitz RA, Henson PM.
Nature 2000 May; 405(6782):85.
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Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis.
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