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Last updated: 2016/12/4
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DNMT3A polyclonal antibody

  • Catalog # : PAB2206
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of DNMT3A.
  • Immunogen:
  • A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human DNMT3A.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Ammonium sulfate precipitation
  • Recommend Usage:
  • Western Blot (1:1000)
    Immunohistochemsitry (1:10-50)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of DNMT3A polyclonal antibody (Cat # PAB2206) in Jurkat cell line lysates (35 ug/lane). DNMT3A (arrow) was detected using the purified polyclonal antibody.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Formalin-fixed and paraffin-embedded human lung carcinomareacted with DNMT3A polyclonal antibody (Cat # PAB2206), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
    This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 1788
  • Protein Accession#:
  • NP_072046;Q9Y6K1
  • Gene Name:
  • DNMT3A
  • Gene Alias:
  • DNMT3A2,M.HsaIIIA
  • Gene Description:
  • DNA (cytosine-5-)-methyltransferase 3 alpha
  • Gene Summary:
  • CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
  • Other Designations:
  • DNA MTase HsaIIIA,DNA cytosine methyltransferase 3 alpha,DNA cytosine methyltransferase 3A2,DNA methyltransferase HsaIIIA,OTTHUMP00000120005,OTTHUMP00000120006
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