GPER polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human gallbladder with GPER polyclonal antibody (Cat # PAB22000) shows strong membranous and cytoplasmic positivity in glandular cells.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant GPER.
Immunogen
Recombinant protein corresponding to amino acids of human GPER.
Sequence
MDVTSQARGVGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLFLS
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human gallbladder with GPER polyclonal antibody (Cat # PAB22000) shows strong membranous and cytoplasmic positivity in glandular cells. -
Gene Info — GPER
Entrez GeneID
2852Protein Accession#
Q99527Gene Name
GPER
Gene Alias
CEPR, CMKRL2, DRY12, FEG-1, GPCR-Br, GPR30, LERGU, LERGU2, LyGPR, MGC99678
Gene Description
G protein-coupled estrogen receptor 1
Omim ID
601805Gene Ontology
HyperlinkGene Summary
This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq
Other Designations
G protein-coupled receptor 30|IL8-related receptor|OTTHUMP00000115502|chemokine receptor-like 2|constitutively expressed peptide-like receptor|flow-induced endothelial G-protein coupled receptor|heptahelix receptor|leucine rich protein in GPR30 3'UTR
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Interactome
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Disease
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Publication Reference
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Estradiol mediates relaxation of porcine lower esophageal sphincter.
Tsai CC, Tey SL, Chang LC, Su YT, Lin KJ, Huang SC.
Steroids 2018 Aug; 136:56.
Application：IHC-P, Pig, Lower esophageal sphincter sling, Clasp, Smooth muscles.
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Estrogen and G protein-coupled estrogen receptor agonist G-1 cause relaxation of human gallbladder.
Lee M, Yang Y, Chen Y, Chang B, Li Y, Huang S.
Ci Ji Yi Xue Za Zhi 2016 May; 28(2):54.
Application：IHC, Human, Human gallbladder muscle.
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Estradiol mediates relaxation of porcine lower esophageal sphincter.
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