SLC19A1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant SLC19A1.
Immunogen
Recombinant protein corresponding to amino acids of human SLC19A1.
Sequence
AQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPVTTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNV
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:200-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human placenta with SLC19A1 polyclonal antibody (Cat # PAB21962) shows strong membranous positivity in trophoblastic cells at 1:200-1:500 dilution. -
Gene Info — SLC19A1
Entrez GeneID
6573Protein Accession#
P41440Gene Name
SLC19A1
Gene Alias
CHMD, FOLT, IFC1, REFC, RFC1
Gene Description
solute carrier family 19 (folate transporter), member 1
Omim ID
600424Gene Ontology
HyperlinkGene Summary
Transport of folate compounds into mammalian cells can occur via receptor-mediated (see MIM 136430) or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.[supplied by OMIM
Other Designations
reduced folate carrier|solute carrier family 19 member 1
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