PEMT polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PEMT.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PEMT.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of PEMT polyclonal antibody (Cat # PAB2194) in T-47D cell line lysates (35 ug/lane). PEMT (arrow) was detected using the purified polyclonal antibody. -
Gene Info — PEMT
Entrez GeneID
10400Protein Accession#
NP_009100;Q9UBM1Gene Name
PEMT
Gene Alias
MGC2483, PEAMT, PEMPT, PEMT2, PNMT
Gene Description
phosphatidylethanolamine N-methyltransferase
Omim ID
602391Gene Ontology
HyperlinkGene Summary
This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. The protein localizes to the endoplasmic reticulum and mitochondria-associated membranes. The gene is within the Smith-Magenis syndrome region on chromosome 17. Alternate splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq
Other Designations
OTTHUMP00000065536|OTTHUMP00000065537
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Interactome
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Pathway
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Disease
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Publication Reference
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Structure, expression profile and alternative processing of the human phosphatidylethanolamine N-methyltransferase (PEMT) gene.
Shields DJ, Agellon LB, Vance DE.
Biochimica et Biophysica Acta 2001 May; 1532(1-2):105.
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Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.
Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL.
PNAS 2000 Aug; 97(17):9543.
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Identification of three novel cDNAs for human phosphatidylethanolamine N-methyltransferase and localization of the human gene on chromosome 17p11.2.
Walkey CJ, Shields DJ, Vance DE.
Biochimica et Biophysica Acta 1999 Jan; 1436(3):405.
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Structure, expression profile and alternative processing of the human phosphatidylethanolamine N-methyltransferase (PEMT) gene.
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