Western blot analysis of Lane 1: Negative control (vector only transfected HEK293T lysate), Lane 2: Over-expression Lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells) with PRDM10 polyclonal antibody (Cat # PAB21861) at 1:250-1:500 dilution.
Immunohistochemical staining of human duodenum with PRDM10 polyclonal antibody (Cat # PAB21861) shows strong nuclear positivity in glandular cells while paneth cells displayed additional strong cytoplasmic positivity at 1:50-1:200 dilution.
The protein encoded by this gene is a transcription factor that contains C2H2-type zinc-fingers. It also contains a positive regulatory domain, which has been found in several other zinc-finger transcription factors including those involved in B cell differentiation and tumor suppression. Studies of the mouse counterpart suggest that this protein may be involved in the development of the central nerve system (CNS), as well as in the pathogenesis of neuronal storage disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq
PR-domain family member 7,PRDM zinc finger transcription factor,tristanin