EDEM3 polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against recombinant EDEM3.
Immunogen
Recombinant protein corresponding to amino acids of human EDEM3.
Sequence
YLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNQSISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPL
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:10-1:20)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human cerebral cortex with EDEM3 polyclonal antibody (Cat # PAB21781) shows distinct positivity in neuropil at 1:10-1:20 dilution. -
Gene Info — EDEM3
Entrez GeneID
80267Protein Accession#
Q9BZQ6Gene Name
EDEM3
Gene Alias
C1orf22
Gene Description
ER degradation enhancer, mannosidase alpha-like 3
Omim ID
610214Gene Ontology
HyperlinkGene Summary
Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM
Other Designations
ER degradation-enhancing -mannosidase-like protein 3
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