PRMT6 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PRMT6.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human PRMT6.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The PRMT6 polyclonal antibody (Cat # PAB2176) was used to detect human PRMT6 protein in human brain extract in a Western blot analysis.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — PRMT6
Entrez GeneID
55170Protein Accession#
AY043278Gene Name
PRMT6
Gene Alias
FLJ10559, HRMT1L6
Gene Description
protein arginine methyltransferase 6
Omim ID
608274Gene Ontology
HyperlinkGene Summary
Protein arginine N-methyltransferases, such as PRMT6, catalyze the sequential transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine.[supplied by OMIM
Other Designations
HMT1 hnRNP methyltransferase-like 6|protein arginine N-methyltransferase 6
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Interactome
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Disease
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Publication Reference
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mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad.
Pal S, Yun R, Datta A, Lacomis L, Erdjument-Bromage H, Kumar J, Tempst P, Sif S.
Molecular and Cellular Biology 2003 Nov; 23(21):7475.
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The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity.
Frankel A, Yadav N, Lee J, Branscombe TL, Clarke S, Bedford MT.
The Journal of Biological Chemistry 2001 Nov; 277(5):3537.
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Prmt5, which forms distinct homo-oligomers, is a member of the protein-arginine methyltransferase family.
Rho J, Choi S, Seong YR, Cho WK, Kim SH, Im DS.
The Journal of Biological Chemistry 2001 Jan; 276(14):11393.
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mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad.
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