Immunohistochemical staining of human colon with TACC1 polyclonal antibody (Cat # PAB21740) shows moderate cytoplasmic positivity in glandular cells at 1:200-1:500 dilution.
Immunofluorescent staining of human cell line U-2 OS with TACC1 polyclonal antibody (Cat # PAB21740) at 1-4 ug/mL dilution shows positivity in cytoskeleton (intermediate filaments) and cytoskeleton (microtubules).
This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
transforming, acidic coiled-coil containing protein 1 variant TACC1-B