FAT1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant FAT1.
Immunogen
Recombinant protein corresponding to amino acids of human FAT1.
Sequence
NFQRALRNILGVRRNDIQIVSLQSSEPHPHLDVLLFVEKPGSAQISTKQLLHKINSSVTDIEEIIGVRILNVFQKLCAGLDCPWKFCDEKVSVDESVMSTHSTARLSFVTPRHHRAAVCLCKEGRCP
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:20-1:50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human placenta with FAT1 polyclonal antibody (Cat # PAB21615) shows strong cytoplasmic positivity in decidual cells at 1:20-1:50 dilution. -
Gene Info — FAT1
Entrez GeneID
2195Protein Accession#
Q14517Gene Name
FAT1
Gene Alias
CDHF7, FAT, ME5, hFat1
Gene Description
FAT tumor suppressor homolog 1 (Drosophila)
Omim ID
600976Gene Ontology
HyperlinkGene Summary
This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq
Other Designations
FAT tumor suppressor 1|cadherin ME5|cadherin family member 7|cadherin-related tumor suppressor
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Interactome
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Disease
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