KIFAP3 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human adrenal gland with KIFAP3 polyclonal antibody (Cat # PAB21603) shows strong nuclear and cytoplasmic positivity in cortical cells at 1:10-1:20 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant KIFAP3.
Immunogen
Recombinant protein corresponding to amino acids of human KIFAP3.
Sequence
KSSKPKDPPPFEGMEIDEVANINDMDEYIELLYEDIPDKVRGSALILQLARNPDNLEELLLNETALGALARVLREDWKQSVELATNIIYIF
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:10-1:20)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human adrenal gland with KIFAP3 polyclonal antibody (Cat # PAB21603) shows strong nuclear and cytoplasmic positivity in cortical cells at 1:10-1:20 dilution. -
Gene Info — KIFAP3
Entrez GeneID
22920Protein Accession#
Q92845Gene Name
KIFAP3
Gene Alias
FLJ22818, KAP3, SMAP, Smg-GDS, dJ190I16.1
Gene Description
kinesin-associated protein 3
Omim ID
601836Gene Ontology
HyperlinkGene Summary
The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. [provided by RefSeq
Other Designations
OTTHUMP00000034158|small G protein GDP dissociation stimulator|smg GDS-associated protein
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Interactome
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Disease
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