Products

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human small intestine with SON polyclonal antibody (Cat # PAB21585) shows strong nuclear positivity in glandular cells.

Immunofluorescence

Immunofluorescent staining of human cell line U-251MG with SON polyclonal antibody (Cat # PAB21585) at 1-4 ug/mL dilution shows positivity in nuclei but not nucleoli.

Entrez GeneID

6651

Protein Accession#

P18583

Gene Name

SON

Gene Alias

BASS1, C21orf50, DBP-5, FLJ21099, FLJ33914, KIAA1019, NREBP, SON3

Gene Description

SON DNA binding protein

Omim ID

182465

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene binds to a specific DNA sequence upstream of the upstream regulatory sequence of the core promoter and second enhancer of human hepatitis B virus (HBV). Through this binding, it represses HBV core promoter activity, transcription of HBV genes, and production of HBV virions. The protein shows sequence similarities with other DNA-binding structural proteins such as gallin, oncoproteins of the MYC family, and the oncoprotein MOS. It may also be involved in protecting cells from apoptosis and in pre-mRNA splicing. Several transcript variants encoding different isoforms have been described for this gene, but the full-length nature of only two of them has been determined. [provided by RefSeq

Other Designations

Bax antagonist selected in Saccharomyces 1|NRE-binding protein|SON DNA-binding protein|negative regulatory element-binding protein