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Last updated: 2016/11/27
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PPM1D polyclonal antibody

  • Catalog # : PAB2151
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of PPM1D.
  • Immunogen:
  • A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PPM1D.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein G purification
  • Recommend Usage:
  • Western Blot (1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • The PPM1D polyclonal antibody (Cat # PAB2151) is used in Western blot to detect PPM1D in 293 cell lysate.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 8493
  • Protein Accession#:
  • NP_003611;O15297
  • Gene Name:
  • PPM1D
  • Gene Alias:
  • PP2C-DELTA,WIP1
  • Gene Description:
  • protein phosphatase 1D magnesium-dependent, delta isoform
  • Gene Summary:
  • The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq
  • Other Designations:
  • p53-induced protein phosphatase 1,protein phosphatase 1D,protein phosphatase 2C delta isoform,protein phosphatase Wip1
  • Gene Pathway
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