PPM1D polyclonal antibody
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More Files
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Western Blot (Cell lysate)
The PPM1D polyclonal antibody (Cat # PAB2151) is used in Western blot to detect PPM1D in 293 cell lysate.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PPM1D.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PPM1D.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The PPM1D polyclonal antibody (Cat # PAB2151) is used in Western blot to detect PPM1D in 293 cell lysate. -
Gene Info — PPM1D
Entrez GeneID
8493Protein Accession#
NP_003611;O15297Gene Name
PPM1D
Gene Alias
PP2C-DELTA, WIP1
Gene Description
protein phosphatase 1D magnesium-dependent, delta isoform
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq
Other Designations
p53-induced protein phosphatase 1|protein phosphatase 1D|protein phosphatase 2C delta isoform|protein phosphatase Wip1
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Interactome
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Disease
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