SLC16A3 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant SLC16A3.
Immunogen
Recombinant protein corresponding to amino acids of human SLC16A3.
Sequence
AEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
Host
Rabbit
Reactivity
Human, Rat
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:50-1:200)
Immunofluorescence (1-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human duodenum with SLC16A3 polyclonal antibody (Cat # PAB21410) strong cytoplasmic positivity in glandular cells.Immunofluorescence
Immunofluorescent staining of human cell line U-251MG with SLC16A3 polyclonal antibody (Cat # PAB21410) at 1-4 ug/mL dilution shows positivity in plasma membrane. -
Gene Info — SLC16A3
Entrez GeneID
9123Protein Accession#
O15427Gene Name
SLC16A3
Gene Alias
MCT3, MCT4, MGC138472, MGC138474
Gene Description
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
Omim ID
603877Gene Ontology
HyperlinkGene Summary
Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM
Other Designations
monocarboxylate transporter 3|monocarboxylate transporter 4|solute carrier family 16 (monocarboxylic acid transporters), member 3|solute carrier family 16, member 3
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Interactome
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Disease
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Publication Reference
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A monocarboxylate transporter-dependent mechanism confers resistance to exercise-induced fatigue in a high-altitude hypoxic environment.
Chen Gao, Binni Yang, Yurong Li, Wenjuan Pei.
Scientific Reports 2023 Feb; 13(1):2949.
Application:IHC-P, WB-Ti, Rat, Rat brain.
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Monocarboxylate transporter-dependent mechanism is involved in the adaptability of the body to exercise-induced fatigue under high-altitude hypoxia environment.
Chen Gao, Binni Yang, Yurong Li, Wenjuan Pei.
Brain Research Bulletin 2023 Apr; 195:78.
Application:Rat-Ti, Rat, Rat cortex.
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Involvement of monocarboxylate transporters in the cross-tolerance between epilepsy and cerebral infarction: a promising choice towards new treatments.
Gao C, Li Z, Bai J, Wang R, Gao L.
Neuroscience Letters 2019 May; 134305.
Application:WB-Ti, Rat, Rat hippocampus.
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Monocarboxylate transporter-dependent mechanism confers resistance to oxygen- and glucose-deprivation injury in astrocyte-neuron co-cultures.
Gao C, Zhou L, Zhu W, Wang H, Wang R, He Y, Li Z.
Neuroscience Letters 2015 May; 594:99.
Application:IF, WB-Tr, Rat, Astrocyte, Astrocyte-siRNA.
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MCT4-Mediated Expression of EAAT1 is Involved in the Resistance to Hypoxia Injury in Astrocyte-Neuron co-Cultures.
Gao C, Zhu W, Tian L, Zhang J, Li Z.
Neurochemical Research 2015 Apr; 40(4):818.
Application:WB-Tr, Rat, Astrocyte-neuron cells.
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Intermittent hypoxia preconditioning-induced epileptic tolerance by upregulation of monocarboxylate transporter 4 expression in rat hippocampal astrocytes.
Gao C, Wang C, Liu B, Wu H, Yang Q, Jin J, Li H, Dong S, Gao G, Zhang H.
Neurochemical Research 2014 Nov; 39(11):2160.
Application:IF, WB-Ce, Rat, Hippocampus astrocytes.
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A monocarboxylate transporter-dependent mechanism confers resistance to exercise-induced fatigue in a high-altitude hypoxic environment.
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