PRCC polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human small intestine with PRCC polyclonal antibody (Cat # PAB21212) shows strong nuclear positivity in glandular cells.
Immunofluorescence
Immunofluorescent staining of human cell line A-431 with PRCC polyclonal antibody (Cat # PAB21212) at 1-4 ug/mL dilution shows positivity in nucleus but not nucleoli.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant PRCC.
Immunogen
Recombinant protein corresponding to amino acids of human PRCC.
Sequence
PDEAEPEPEEEEAVAPTSGPALGGLFASLPAPKGPALLPPPPQMLAPAFPPPLLLPPPTGDPRLQPPPPLPFGLGGFPPPPGVSPAEAAGVGEGLGLGLPS
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:20-1:50)
Immunofluorescence (1-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human small intestine with PRCC polyclonal antibody (Cat # PAB21212) shows strong nuclear positivity in glandular cells.Immunofluorescence
Immunofluorescent staining of human cell line A-431 with PRCC polyclonal antibody (Cat # PAB21212) at 1-4 ug/mL dilution shows positivity in nucleus but not nucleoli. -
Gene Info — PRCC
Entrez GeneID
5546Protein Accession#
Q92733Gene Name
PRCC
Gene Alias
MGC17178, MGC4723, RCCP1, TPRC
Gene Description
papillary renal cell carcinoma (translocation-associated)
Gene Ontology
HyperlinkGene Summary
In a subset of papillary renal cell carcinomas, a t(X;1)(p11;q21) chromosome translocation has been repeatedly reported and is thought to be the cause of the cancer. As a result of the translocation, the transcription factor TFE3 on the X chromosome becomes fused to this gene on chromosome 1. The fused gene results in the fusion of N-terminal proline-rich region of the protein encoded by this gene to the entire TFE3 protein. This protein has been shown to interact with the mitotic checkpoint protein MAD2B, which suggests that the dominant-negative effect of the fusion protein with TFE3 may lead to a mitotic checkpoint defect. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq
Other Designations
OTTHUMP00000038719|papillary renal cell carcinoma translocation-associated gene product|proline-rich protein PRCC
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