CHN2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant CHN2.
Immunogen
Recombinant protein corresponding to amino acids of human CHN2.
Sequence
ASSNSSLSGSSVSSDAEEYQPPIWKSYLYQLQQEAPRPKRIICPREVENRPKY
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:20-1:50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human colon with CHN2 polyclonal antibody (Cat # PAB21183) shows strong cytoplasmic positivity in granular pattern in glandular cells at 1:20-1:50 dilution. -
Gene Info — CHN2
Entrez GeneID
1124Protein Accession#
P52757Gene Name
CHN2
Gene Alias
ARHGAP3, BCH, MGC138360, RHOGAP3
Gene Description
chimerin (chimaerin) 2
Omim ID
602857Gene Ontology
HyperlinkGene Summary
This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
beta chimerin|rho-GTPase-activating protein 3
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Interactome
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Disease
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