PPM1E polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human cerebellum with PPM1E polyclonal antibody (Cat # PAB21168) shows distinct nucleolar and nuclear positivity in Purkinje cells and in cells in molecular layer.
Immunofluorescence
Immunofluorescent staining of human cell line U-2 OS with PPM1E polyclonal antibody (Cat # PAB21168) at 1-4 ug/mL dilution shows positivity in nucleus and nucleoli.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant PPM1E.
Immunogen
Recombinant protein corresponding to amino acids of human PPM1E.
Sequence
EVEGESLDLCLQQLYKYNCPSFLAAALARATSDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEI
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:10-1:20)
Immunofluorescence (1-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human cerebellum with PPM1E polyclonal antibody (Cat # PAB21168) shows distinct nucleolar and nuclear positivity in Purkinje cells and in cells in molecular layer.Immunofluorescence
Immunofluorescent staining of human cell line U-2 OS with PPM1E polyclonal antibody (Cat # PAB21168) at 1-4 ug/mL dilution shows positivity in nucleus and nucleoli. -
Gene Info — PPM1E
Entrez GeneID
22843Protein Accession#
Q8WY54Gene Name
PPM1E
Gene Alias
DKFZp781F1422, KIAA1072, POPX1, PP2CH
Gene Description
protein phosphatase 1E (PP2C domain containing)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase was identified as an interacting protein of Rho guanine nucleotide exchange factors (PIX). PIX proteins are regulators of p21/Cdc42/Rac1-activated kinase 1 (PAK1), a protein kinase mediating biological effects downstream of Rho GTPases. This phosphatase has been shown to block the effects of PAK, and thus inhibit actin stress fiber breakdown and morphological changes driven by cell division cycle 42 (CDC42). [provided by RefSeq
Other Designations
partner of PIX 1|protein phosphatase 1E
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Interactome
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Disease
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