PCNT polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human exocrine pancreas with PCNT polyclonal antibody (Cat # PAB21142) shows spot-like perinuclear positivity.
Immunofluorescence
Immunofluorescent staining of human cell line U-2 OS with PCNT polyclonal antibody (Cat # PAB21142) at 1-4 ug/mL dilution shows positivity in centrosome.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant PCNT.
Immunogen
Recombinant protein corresponding to amino acids of human PCNT.
Sequence
MEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVEDLEQLKQREKTQHESELE
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:200-1:500)
Immunofluorescence (1-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human exocrine pancreas with PCNT polyclonal antibody (Cat # PAB21142) shows spot-like perinuclear positivity.Immunofluorescence
Immunofluorescent staining of human cell line U-2 OS with PCNT polyclonal antibody (Cat # PAB21142) at 1-4 ug/mL dilution shows positivity in centrosome. -
Gene Info — PCNT
Entrez GeneID
5116Protein Accession#
O95613Gene Name
PCNT
Gene Alias
KEN, MOPD2, PCN, PCNT2, PCNTB, PCTN2, SCKL4
Gene Description
pericentrin
Omim ID
605925Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. [provided by RefSeq
Other Designations
kendrin|pericentrin B|pericentrin-2|pericentrin-380
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Interactome
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Disease
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