OGDH polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human heart muscle with OGDH polyclonal antibody (Cat # PAB21069) shows strong cytoplasmic positivity.
Immunofluorescence
Immunofluorescent staining of human cell line U-251MG with OGDH polyclonal antibody (Cat # PAB21069) at 1-4 ug/mL dilution shows positivity in mitochondria.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant OGDH.
Immunogen
Recombinant protein corresponding to amino acids of human OGDH.
Sequence
LRTCAAKLRPLTASQTVKTFSQNRPAAARTFQQIRCYSAPVAAEPFLSGTSSNYVEEMYCAWLENPKSV
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:20-1:50)
Immunofluorescence (1-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human heart muscle with OGDH polyclonal antibody (Cat # PAB21069) shows strong cytoplasmic positivity.Immunofluorescence
Immunofluorescent staining of human cell line U-251MG with OGDH polyclonal antibody (Cat # PAB21069) at 1-4 ug/mL dilution shows positivity in mitochondria. -
Gene Info — OGDH
Entrez GeneID
4967Protein Accession#
Q02218Gene Name
OGDH
Gene Alias
AKGDH, E1k, OGDC
Gene Description
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Omim ID
203740Gene Ontology
HyperlinkGene Summary
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms
Other Designations
2-oxoglutarate dehydrogenase|H_DJ0691F11_gi16307008.sp_cds.1|oxoglutarate decarboxylase'|oxoglutarate dehydrogenase (lipoamide)|oxoglutarate dehydrogenase (succinyl-transferring)
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Interactome
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Pathway
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from ornithine
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Citrate cycle (TCA cycle)
- Lysine degradation
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