TMEM43 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human esophagus with TMEM43 polyclonal antibody (Cat # PAB21064) shows cytoplasmic positivity in basal layer of squamous epithelial cells and distinct staining in endothelial cells.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant TMEM43.
Immunogen
Recombinant protein corresponding to amino acids of human TMEM43.
Sequence
FKSLSLSKLEDPHVDIIRRGDFFYHSENPKYPEVGDLRVSFSYAGLSGDDPDLGPAHVVTVIARQRGDQLVPFSTKSGDTLLLLHHGDFSAEEVFHRELRSNSMKT
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human esophagus with TMEM43 polyclonal antibody (Cat # PAB21064) shows cytoplasmic positivity in basal layer of squamous epithelial cells and distinct staining in endothelial cells. -
Gene Info — TMEM43
Entrez GeneID
79188Protein Accession#
Q9BTV4Gene Name
TMEM43
Gene Alias
ARVC5, ARVD5, DKFZp586G1919, LUMA, MGC3222
Gene Description
transmembrane protein 43
Gene Ontology
HyperlinkGene Summary
This gene belongs to the TMEM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC. [provided by RefSeq
Other Designations
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Interactome
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Disease
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