MCOLN2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant MCOLN2.
Immunogen
Recombinant protein corresponding to amino acids of human MCOLN2.
Sequence
YHQLKDITLGTLGYGENEDNRIGLKVCKQHYKKGTMFPSNETLNIDNDVELDCVQLDLQDLSKKPPDWKNSSFFRLEFYR
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:200-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human testis with MCOLN2 polyclonal antibody (Cat # PAB21061) shows strong nuclear positivity in cells of ductus seminiferus. -
Gene Info — MCOLN2
Entrez GeneID
255231Protein Accession#
Q8IZK6Gene Name
MCOLN2
Gene Alias
FLJ36691, TRP-ML2, TRPML2
Gene Description
mucolipin 2
Omim ID
607399Gene Ontology
HyperlinkGene Summary
Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]).[supplied by OMIM
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