GUCA2A polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant GUCA2A.
Immunogen
Recombinant protein corresponding to amino acids of human GUCA2A.
Sequence
SLESVKKLKDLQEPQEPRVGKLRNFAPIPGEPVVPILCSNPNFPEELKPLCKEPNAQEILQRLEEIAEDPGTCEICAYAACTGC
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of Lane 1: Negative control (vector only transfected HEK293T lysate).
Lane 2: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells with GUCA2A polyclonal antibody (Cat # PAB21024).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human small intestine with GUCA2A polyclonal antibody (Cat # PAB21024) strong cytoplasmic positivity in glandular cells. -
Gene Info — GUCA2A
Entrez GeneID
2980Protein Accession#
Q02747Gene Name
GUCA2A
Gene Alias
GUANYLIN, GUCA2, STARA
Gene Description
guanylate cyclase activator 2A (guanylin)
Omim ID
139392Gene Ontology
HyperlinkGene Summary
intestinal
Other Designations
OTTHUMP00000007926|guanylate cyclase activator 2A|guanylate cyclase activator 2A (guanylin 2, intestinal, heat-stable)
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Interactome
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Publication Reference
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Uroguanylin prevents hepatic steatosis, mitochondrial dysfunction and fibrosis in obesity-associated NAFLD.
Eva M Fernández-Sáez, Maite Losarcos, Sara Becerril, Víctor Valentí, Rafael Moncada, Marina Martín, María A Burrell, Victoria Catalán, Javier Gómez-Ambrosi, Carmen Mugueta, Inmaculada Colina, Camilo Silva, Javier Escalada, Gema Frühbeck, Amaia Rodríguez.
Metabolism: Clinical and Experimental 2023 Jul; 147:1556633.
Application:IHC-P, Human, Human Liver.
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High plasma and lingual uroguanylin as potential contributors to changes in food preference after sleeve gastrectomy.
Gema Frühbeck, Sara Becerril, Marina Martín, Beatriz Ramírez, Víctor Valentí, Rafael Moncada, Victoria Catalán, Javier Gómez-Ambrosi, Camilo Silva, María A Burrell, Javier Escalada, Amaia Rodríguez.
Metabolism: Clinical and Experimental 2022 Mar; 128:155119.
Application:WB, Rat, Rat tongues.
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Uroguanylin prevents hepatic steatosis, mitochondrial dysfunction and fibrosis in obesity-associated NAFLD.
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