PDX1 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PDX1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PDX1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of PDX1 polyclonal antibody (Cat # PAB2102) in HepG2 cell line lysates (35 ug/lane). IPF (arrow) was detected using the purified Polyclonal antibody. -
Gene Info — PDX1
Entrez GeneID
3651Protein Accession#
NP_000200;P52945Gene Name
PDX1
Gene Alias
GSF, IDX-1, IPF1, IUF1, MODY4, PDX-1, STF-1
Gene Description
pancreatic and duodenal homeobox 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq
Other Designations
OTTHUMP00000018174|glucose-sensitive factor|insulin promoter factor 1, homeodomain transcription factor|insulin upstream factor 1|pancreatic-duodenal homeobox factor 1|somatostatin transcription factor 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Pancreatic duodenal homeobox-1 (PDX1) functions as a tumor suppressor in gastric cancer.
Ma J, Chen M, Wang J, Xia HH, Zhu S, Liang Y, Gu Q, Qiao L, Dai Y, Zou B, Li Z, Zhang Y, Lan H, Wong BC.
Carcinogenesis 2008 Jul; 29(7):1327.
Application:IHC-P, WB-Tr, Human, Human chronic gastritis tissues, normal and metaplastic tissues adjacent to gastric cancer and cancer tissues, SGC7901 cells.
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Involvement of the homeodomain-containing transcription factor PDX-1 in islet amyloid polypeptide gene transcription.
Watada H, Kajimoto Y, Kaneto H, Matsuoka T, Fujitani Y, Miyazaki J, Yamasaki Y.
Biochemical and Biophysical Research Communications 1996 Dec; 229(3):746.
Application:GSA, Mouse, MIN6 cells.
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Pancreatic duodenal homeobox-1 (PDX1) functions as a tumor suppressor in gastric cancer.
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