ATP6V0A4 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant ATP6V0A4.
Immunogen
Recombinant protein corresponding to amino acids of human ATP6V0A4.
Sequence
RASHRKSQLQASRIQEDATENIEGDSSSPSSRSGQRTSADTHGALDDHGEEFNFGDVFVHQAIHTIEYCLGCISNTAS
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human kidney with ATP6V0A4 polyclonal antibody (Cat # PAB21000) shows strong cytoplasmic positivity in cells in tubules at 1:50-1:200 dilution. -
Gene Info — ATP6V0A4
Entrez GeneID
50617Protein Accession#
Q9HBG4Gene Name
ATP6V0A4
Gene Alias
A4, ATP6N1B, ATP6N2, MGC130016, MGC130017, RDRTA2, RTA1C, RTADR, STV1, VPH1, VPP2
Gene Description
ATPase, H+ transporting, lysosomal V0 subunit a4
Gene Ontology
HyperlinkGene Summary
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing. [provided by RefSeq
Other Designations
ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1B|ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kD)|H(+)-transporting two-sector ATPase, noncatalytic accessory pro
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