Products

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human skeletal muscle with ITSN1 polyclonal antibody (Cat # PAB20995) shows moderate cytoplasmic positivity in myocytes at 1:200-1:500 dilution.

Immunofluorescence

Immunofluorescent staining of human cell line A-431 with ITSN1 polyclonal antibody (Cat # PAB20995) at 1-4 ug/mL dilution shows positivity in plasma membrane.

Entrez GeneID

6453

Protein Accession#

Q15811

Gene Name

ITSN1

Gene Alias

ITSN, MGC134948, MGC134949, SH3D1A, SH3P17

Gene Description

intersectin 1 (SH3 domain protein)

Omim ID

602442

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. [provided by RefSeq

Other Designations

OTTHUMP00000067855|SH3 domain protein-1A|Src homology 3 domain-containing protein|human intersectin-SH3 domain-containing protein SH3P17|intersectin 1|intersectin 1 short form variant 11|intersectin 1 short form variant 3|intersectin short variant 12