Products

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human rectum with SPEN polyclonal antibody (Cat # PAB20849) shows strong nuclear and slightly weaker cytoplasmic positivity in glandular cells.

Immunofluorescence

Immunofluorescent staining of human cell line U-251 MG with SPEN polyclonal antibody (Cat # PAB20849) at 1-4 ug/mL dilution shows positivity in nuclei but not nucleoli.

Entrez GeneID

23013

Protein Accession#

Q96T58

Gene Name

SPEN

Gene Alias

KIAA0929, MINT, RP1-134O19.1, SHARP

Gene Description

spen homolog, transcriptional regulator (Drosophila)

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. [provided by RefSeq

Other Designations

Msx2 interacting nuclear target (MINT) homolog|OTTHUMP00000010982|OTTHUMP00000044600|SMART/HDAC1 associated repressor protein|nuclear receptor transcription cofactor|spen homolog, transcriptional regulator