PLCE1 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human colon with PLCE1 polyclonal antibody (Cat # PAB20820) shows strong cytoplasmic positivity in plasma cells.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant PLCE1.
Immunogen
Recombinant protein corresponding to amino acids of human PLCE1.
Sequence
MGISPLGNQSVIIETGRAHPDSRRAVFHFHYEVDRRMSDTFCTLSENLILDDCGNCVPLPGGEEKQKKNYVAYTCKLMELAKNCDNKNEQLQCDHCDTLNDKYFCFEGSCEKVDMVYSGDSFCRKDFTDSQAAKT
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human colon with PLCE1 polyclonal antibody (Cat # PAB20820) shows strong cytoplasmic positivity in plasma cells. -
Gene Info — PLCE1
Entrez GeneID
51196Protein Accession#
Q9P212Gene Name
PLCE1
Gene Alias
FLJ23659, KIAA1516, MGC167842, NPHS3, PLCE
Gene Description
phospholipase C, epsilon 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms
Other Designations
nephrosis type 3|pancreas-enriched phospholipase C
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Interactome
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Pathway
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Disease
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Publication Reference
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Functional role of PLCE1 intronic insertion variant associated with susceptibility to esophageal squamous-cell carcinoma.
Wei L, Shao M, Zhao Y, Zheng J, Chu J, Chang J, Cheng X, Qionghua C, Peng L, Luo Y, Tan W, Tan W, Lin D, Wu C.
Carcinogenesis 2018 Feb; 39(2):191.
Application：WB-Tr, WB-Ti, Human , BxPC-3, H1299, H460, KYSE30, KYSE150, RKO cells, normal esophageal tissues.
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Functional role of PLCE1 intronic insertion variant associated with susceptibility to esophageal squamous-cell carcinoma.
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