Products

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human adrenal gland with PCDHB4 polyclonal antibody (Cat # PAB20726) shows strong cytoplasmic positivity in cortical cells.

Immunofluorescence

Immunofluorescent staining of human cell line U-251 MG with PCDHB4 polyclonal antibody (Cat # PAB20726) at 1-4 ug/mL dilution shows positivity in plasma membrane, cytoplasm.

Entrez GeneID

56131

Protein Accession#

Q9Y5E5

Gene Name

PCDHB4

Gene Alias

PCDH-BETA4

Gene Description

protocadherin beta 4

Omim ID

606330

Gene Ontology

Hyperlink

Gene Summary

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq

Other Designations

-