ATP7A polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human hippocampus with ATP7A polyclonal antibody (Cat # PAB20632) shows strong cytoplasmic positivity in neuronal cells and glial cells at 1:10-1:20 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant ATP7A.
Immunogen
Recombinant protein corresponding to amino acids of human ATP7A.
Sequence
TETLGTCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSSMIIDAQISNALNAQQYKVLIGNREWMIRNGLVINNDVNDFMTEHERKGRTAVLVAVDDELC
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:10-1:20)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human hippocampus with ATP7A polyclonal antibody (Cat # PAB20632) shows strong cytoplasmic positivity in neuronal cells and glial cells at 1:10-1:20 dilution. -
Gene Info — ATP7A
Entrez GeneID
538Protein Accession#
Q04656Gene Name
ATP7A
Gene Alias
FLJ17790, MK, MNK
Gene Description
ATPase, Cu++ transporting, alpha polypeptide
Gene Ontology
HyperlinkGene Summary
This gene encodes a transmembrane protein that functions in copper transport across membranes. The protein localizes to the trans-Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. The protein relocalizes to the plasma membrane under conditions of elevated extracellular copper and functions in the efflux of copper from cells. Mutations in this gene result in Menkes disease, X-linked cutis laxa, and occipital horn syndrome. [provided by RefSeq
Other Designations
Cu++-transporting P-type ATPase|Menkes disease-associated protein|Menkes syndrome|OTTHUMP00000023593|OTTHUMP00000062077|copper pump 1|copper-transporting ATPase 1
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