SCNN1A polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant SCNN1A.
Immunogen
Recombinant protein corresponding to amino acids of human SCNN1A.
Sequence
RYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQL
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:200-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human gallbladder with SCNN1A polyclonal antibody (Cat # PAB20617) shows strong cytoplasmic and membranous positivity in glandular cells at 1:200-1:500 dilution. -
Gene Info — SCNN1A
Entrez GeneID
6337Protein Accession#
P37088Gene Name
SCNN1A
Gene Alias
ENaCa, ENaCalpha, FLJ21883, SCNEA, SCNN1
Gene Description
sodium channel, nonvoltage-gated 1 alpha
Gene Ontology
HyperlinkGene Summary
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
Other Designations
alpha ENaC-2|amiloride-sensitive epithelial sodium channel alpha subunit|nasal epithelial sodium channel alpha subunit
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