OTOF polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant OTOF.
Immunogen
Recombinant protein corresponding to amino acids of human OTOF.
Sequence
PIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNL
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human stomach with OTOF polyclonal antibody (Cat # PAB20599) shows strong cytoplasmic positivity in glandular cells at 1:50-1:200 dilution. -
Gene Info — OTOF
Entrez GeneID
9381Protein Accession#
Q9HC10Gene Name
OTOF
Gene Alias
DFNB6, DFNB9, FER1L2, NSRD9
Gene Description
otoferlin
Gene Ontology
HyperlinkGene Summary
Mutations in this gene are a cause of neurosensory nonsyndromic recessive deafness, DFNB9. The short form of the encoded protein has 3 C2 domains, a single carboxy-terminal transmembrane domain found also in the C. elegans spermatogenesis factor FER-1 and human dysferlin, while the long form has 6 C2 domains. The homology suggests that this protein may be involved in vesicle membrane fusion. Several transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000122454|OTTHUMP00000122455
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Interactome
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Disease
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