Products

Western Blot

Western blot analysis of Lane 1: RT-4, Lane 2: U-251 MG, Lane 3: Human Plasma, Lane 4: Liver, Lane 5: Tonsil with SORCS1 polyclonal antibody (Cat # PAB20572) at 1:250-1:500 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human colon with SORCS1 polyclonal antibody (Cat # PAB20572) shows strong cytoplasmic and membranous positivity in glandular cells at 1:50-1:200 dilution.

Entrez GeneID

114815

Protein Accession#

Q8WY21

Gene Name

SORCS1

Gene Alias

FLJ41758, FLJ43475, FLJ44957

Gene Description

sortilin-related VPS10 domain containing receptor 1

Omim ID

606283

Gene Ontology

Hyperlink

Gene Summary

This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq

Other Designations

OTTHUMP00000020446|OTTHUMP00000058855|SORCS receptor 1|VPS10 domain receptor SorCS|VPS10 domain receptor protein SORCS 1