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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human duodenum with MRVI1 polyclonal antibody (Cat # PAB20443) shows strong cytoplasmic positivity in glandular cells at 1:50-1:200 dilution.

Entrez GeneID

10335

Protein Accession#

Q9Y6F6

Gene Name

MRVI1

Gene Alias

IRAG, JAW1L

Gene Description

murine retrovirus integration site 1 homolog

Omim ID

604673

Gene Ontology

Hyperlink

Gene Summary

This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during lymphoid differentiation. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, few of which initiate translation at a non-AUG (CUG) start site. [provided by RefSeq

Other Designations

IP3R-associated cGMP kinase substrate|JAW1-related protein|inositol 1,4,5-triphosphate-associated cGMP kinase substrate