TGFBR3 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant TGFBR3.
Immunogen
Recombinant protein corresponding to amino acids of human TGFBR3.
Sequence
GYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSGWPDGYEDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLF
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human testis with TGFBR3 polyclonal antibody (Cat # PAB20417) shows strong cytoplasmic positivity in Leydig cells and weak staining in cells of seminiferus ducts at 1:50-1:200 dilution. -
Gene Info — TGFBR3
Entrez GeneID
7049Protein Accession#
Q03167Gene Name
TGFBR3
Gene Alias
BGCAN, betaglycan
Gene Description
transforming growth factor, beta receptor III
Omim ID
600742Gene Ontology
HyperlinkGene Summary
Transforming growth factor (TGF)-beta is a multifunctional cytokine that modulates several tissue development and repair processes, including cell differentiation, cell cycle progression, cellular migration, adhesion, and extracellular matrix production. Three TGF-beta forms are encoded by separate genes: TGFB1 (MIM 190180), TGFB2 (MIM 190220), and TGFB3 (MIM 190230). The diverse effects of TGF-beta are mediated by the TGF-beta receptors and cell surface-binding proteins. Three TGF-beta receptors exist: type I (TGFBR1; MIM 190181), type II (TFGBR2; MIM 190182), and type III (TGFBR3). TGFBR3 is a glycoprotein that binds TGFB and exists in both a membrane-bound and a soluble form (Johnson et al., 1995 [PubMed 8530052]).[supplied by OMIM
Other Designations
betaglycan proteoglycan
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Interactome
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Disease
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