Products

Western Blot (Cell lysate)

Western blot analysis of cell lysates with PPP1R13B polyclonal antibody (Cat # PAB20346) at 1:250-1:500 dilution.
Lane 1 : NIH/3T3
Lane 2 : NBT-II

Western Blot

Western blot analysis of Lane 1: RT-4, Lane 2: U-251 MG, Lane 3: Human Plasma, Lane 4: Liver, Lane 5: Tonsil with PPP1R13B polyclonal antibody (Cat # PAB20346) at 1:250-1:500 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human cerebral cortex with PPP1R13B polyclonal antibody (Cat # PAB20346) shows strong nuclear and cytoplasmic positivity in neuronal cells, glial cells displayed nuclear staining.

Immunofluorescence

Immunofluorescent staining of human cell line U-251 MG with PPP1R13B polyclonal antibody (Cat # PAB20346) at 1-4 ug/mL dilution shows positivity in nucleus but not nucleoli, cytoplasm.

Entrez GeneID

23368

Protein Accession#

Q96KQ4

Gene Name

PPP1R13B

Gene Alias

ASPP1, KIAA0771, p53BP2-like, p85

Gene Description

protein phosphatase 1, regulatory (inhibitor) subunit 13B

Omim ID

606455

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq

Other Designations

apoptosis-stimulating protein of p53, 1