SH2B3 polyclonal antibody
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More Files
- More Functions
Western Blot
Western blot analysis of Lane 1: RT-4, Lane 2: U-251 MG, Lane 3: Human Plasma, Lane 4: Liver, Lane 5: Tonsil with SH2B3 polyclonal antibody (Cat # PAB20298) at 1:250-1:500 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human lymph node with SH2B3 polyclonal antibody (Cat # PAB20298) shows strong nuclear membrane positivity in reaction center cells and lymphoid cells outside reaction center at 1:20-1:50 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant SH2B3.
Immunogen
Recombinant protein corresponding to amino acids of human SH2B3.
Sequence
FDPPKSSRPKLQAACSSIQEVRRCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFH
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:20-1:50)
Western Blot (1:250-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of Lane 1: RT-4, Lane 2: U-251 MG, Lane 3: Human Plasma, Lane 4: Liver, Lane 5: Tonsil with SH2B3 polyclonal antibody (Cat # PAB20298) at 1:250-1:500 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human lymph node with SH2B3 polyclonal antibody (Cat # PAB20298) shows strong nuclear membrane positivity in reaction center cells and lymphoid cells outside reaction center at 1:20-1:50 dilution. -
Gene Info — SH2B3
Entrez GeneID
10019Protein Accession#
Q9UQQ2Gene Name
SH2B3
Gene Alias
CELIAC13, LNK
Gene Description
SH2B adaptor protein 3
Omim ID
605093Gene Ontology
HyperlinkGene Summary
T-cell activation requires stimulation of the T-cell receptor (TCR; see MIM 186880)-CD3 (see CD3Z; MIM 186780) complex, followed by recruitment of an array of intracellular signaling proteins (e.g., GRB2 (MIM 108355) and PLCG1 (MIM 172420)). Mediating the interaction between the extracellular receptors and intracellular signaling pathways are adaptor proteins such as LAT (MIM 602354), TRIM (MIM 604962), and LNK.[supplied by OMIM
Other Designations
lymphocyte adaptor protein
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Interactome
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Pathway
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Disease
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