PANK3 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PANK3.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human PANK3.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of PANK3 polyclonal antibody (Cat # PAB2029) in mouse liver tissue lysate (35 ug/lane). PANK3 (arrow) was detected using the purified Polyclonal antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with PANK3 polyclonal antibody (Cat # PAB2029) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — PANK3
Entrez GeneID
79646Protein Accession#
NP_078870;Q9H999Gene Name
PANK3
Gene Alias
FLJ12899, MGC16863
Gene Description
pantothenate kinase 3
Omim ID
606161Gene Ontology
HyperlinkGene Summary
This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is expressed most abundantly in the liver. [provided by RefSeq
Other Designations
pantothenic acid kinase
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Interactome
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Pathway
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Publication Reference
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A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome.
Zhou B, Westaway SK, Levinson B, Johnson MA, Gitschier J, Hayflick SJ.
Nature Genetics 2001 Aug; 28(4):345.
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A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome.
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