ROBLD3 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant ROBLD3.
Immunogen
Recombinant protein corresponding to amino acids of human ROBLD3.
Sequence
RPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDNLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEP
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:50-1:200)
Western Blot (1:250-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of Lane 1: Negative control (vector only transfected HEK293T lysate), Lane 2: Over-expression Lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells with ROBLD3 polyclonal antibody (Cat # PAB20265) at 1:250-1:500 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human stomach with ROBLD3 polyclonal antibody (Cat # PAB20265) shows strong cytoplasmic positivity in glandular cells at 1:50-1:200 dilution. -
Gene Info — ROBLD3
Entrez GeneID
28956Protein Accession#
Q9Y2Q5Gene Name
ROBLD3
Gene Alias
ENDAP, HSPC003, MAPBPIP, MAPKSP1AP, p14
Gene Description
roadblock domain containing 3
Gene Ontology
HyperlinkGene Summary
The product of this gene is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the mitogen-activated protein kinase pathway. In humans, a mutation in this gene has been associated with a primary immunodeficiency syndrome, and suggests a role for this protein in endosomal biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
MAPKSP1 adaptor protein|OTTHUMP00000018850|endosomal adaptor protein|mitogen activated protein binding protein interacting protein|mitogen-activated protein-binding protein-interacting protein|mitogen-activated protein-binding protein-interacting protein
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Interactome
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