ABCD4 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant ABCD4.
Immunogen
Recombinant protein corresponding to amino acids of human ABCD4.
Sequence
TLVSKNAFVCIYLISCFTQLIDLSTTLSDVAGYTHRIGQLRETLLDMSLKSQDCEILGESEWGLDTPPGWPAAEPADTAFLLERVSISAPSSDKPLIKDLSLKISEGQSLLITGNTGTGK
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:200-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human kidney with ABCD4 polyclonal antibody (Cat # PAB20205) shows moderate cytoplasmic positivity in cells in tubules at 1:200-1:500 dilution. -
Gene Info — ABCD4
Entrez GeneID
5826Protein Accession#
O14678Gene Name
ABCD4
Gene Alias
ABC41, EST352188, P70R, P79R, PMP69, PXMP1L
Gene Description
ATP-binding cassette, sub-family D (ALD), member 4
Omim ID
603214Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. Alternative splicing results in at least two different transcript variants, one which is protein-coding and one which is probably not protein-coding. [provided by RefSeq
Other Designations
69 kDa peroxisomal ABC-transporter|ATP-binding cassette, sub-family D, member 4|peroxisomal membrane protein 1-like|peroxisomal membrane protein 69
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Interactome
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Pathway
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