CD2AP polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant CD2AP.
Immunogen
Recombinant protein corresponding to amino acids of human CD2AP.
Sequence
WSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKE
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:50-1:200)
Western Blot (1:250-1:500)
Immunofluorescence (1-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of Lane 1: RT-4, Lane 2: U-251 MG, Lane 3: Human Plasma, Lane 4: Liver, Lane 5: Tonsil with CD2AP polyclonal antibody (Cat # PAB20186) at 1:250-1:500 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human colon with CD2AP polyclonal antibody (Cat # PAB20186) shows strong cytoplasmic positivity in glandular cells at 1:50-1:200 dilution.Immunofluorescence
Immunofluorescent staining of human cell line U-251 MG with CD2AP polyclonal antibody (Cat # PAB20186) at 1-4 ug/mL dilution shows positivity in plasma membrane, cytoplasm. -
Gene Info — CD2AP
Entrez GeneID
23607Protein Accession#
Q9Y5K6Gene Name
CD2AP
Gene Alias
CMS, DKFZp586H0519
Gene Description
CD2-associated protein
Gene Ontology
HyperlinkGene Summary
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease. [provided by RefSeq
Other Designations
Cas ligand with multiple Src homology 3 (SH3) domains|adapter protein CMS
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Interactome
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Disease
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